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Abstract #2019

Conduction velocity mapping a transcallosal pathway through a correlative multimodal structure-function relationship

Christian Stald Skoven1, Mariam Andersson1, Marco Pizzolato1,2,3, Bente Pakkenberg4,5, Hartwig Roman Siebner1,5,6, and Tim Bjørn Dyrby1,3
1Danish Research Centre for Magnetic Resonance (DRCMR), Copenhagen Universital Hospital Amager and Hvidovre, Copenhagen, Hvidovre, Denmark, 2Signal Processing Lab (LTS5), École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 3Department of Applied Mathematics and Computer Science, Technical University of Denmark (DTU), Kgs. Lyngby, Denmark, 4Research Laboratory for Stereology and Neuroscience, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark, 5Department of Clinical Medicine, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark, 6Department of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark


The structure-function relationship of axons within the intact brain proves challenging to delineate. We recorded transcallosal conduction time in the rat brain with optogenetics and electrophysiology, estimated pathway length with tractography, - and axon diameters (AD) with dw-MRI and transmission electron microscopy. The modalities exhibit different sensitivity profiles. Recorded latencies correspond only to smaller axons below the mode of the distribution of ADs from histology. dw-MRI is only sensitive to larger axons, not accounted for by electrophysiology and only sparsely with histology. Future correlative studies should choose modalities with a sufficient sensitivity profile for the structural or functional metric of interest.

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