Abstract #2019

Conduction velocity mapping a transcallosal pathway through a correlative multimodal structure-function relationship

Christian Stald Skoven¹, Mariam Andersson¹, Marco Pizzolato^1,2,3, Bente Pakkenberg^4,5, Hartwig Roman Siebner^1,5,6, and Tim Bjørn Dyrby^1,3

¹Danish Research Centre for Magnetic Resonance (DRCMR), Copenhagen Universital Hospital Amager and Hvidovre, Copenhagen, Hvidovre, Denmark, ²Signal Processing Lab (LTS5), École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ³Department of Applied Mathematics and Computer Science, Technical University of Denmark (DTU), Kgs. Lyngby, Denmark, ⁴Research Laboratory for Stereology and Neuroscience, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark, ⁵Department of Clinical Medicine, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark, ⁶Department of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark

Synopsis

The structure-function relationship of axons within the intact brain proves challenging to delineate. We recorded transcallosal conduction time in the rat brain with optogenetics and electrophysiology, estimated pathway length with tractography, - and axon diameters (AD) with dw-MRI and transmission electron microscopy. The modalities exhibit different sensitivity profiles. Recorded latencies correspond only to smaller axons below the mode of the distribution of ADs from histology. dw-MRI is only sensitive to larger axons, not accounted for by electrophysiology and only sparsely with histology. Future correlative studies should choose modalities with a sufficient sensitivity profile for the structural or functional metric of interest.

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