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Abstract #2020

A Neurochemical Atlas of the Cingulate Cortex in Relation to Pain.

Jessica Archibald1, Erin L. MacMillan2,3, Niklaus Zölch4, and John L.K. Kramer5
1Experimental Medicine, University of British Columbia, Vancouver, BC, Canada, 2Radiology, University of British Comulbia, Vancouver, BC, Canada, 3Philips, Vancouver, BC, Canada, 4Wissenschaftlicher Mitarbeiter Forensische Medizin und Bildgebung, Universität Zürich, Zürich, Switzerland, 5Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada


1H-MRS provides a window into brain chemistry without the need to directly sample tissue. The growing prevalence of neurological conditions highlight the need for evidence based treatments. Specifically, preclinical and clinical evidence suggest a link between glutamate and pain. This study shows spatial neurochemical differences from different voxels across the cingulate cortex using sLASER at 3 T. A significant correlation between pain ratings and the anterior cingulate cortex is seen. As MRS moves towards becoming a standardized clinical technique, understanding the spatial distributions and variability will provide an important basis for the understanding of the healthy human brain’s biochemical environment.

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