1H-MRS provides a window into brain chemistry without the need to directly sample tissue. The growing prevalence of neurological conditions highlight the need for evidence based treatments. Specifically, preclinical and clinical evidence suggest a link between glutamate and pain. This study shows spatial neurochemical differences from different voxels across the cingulate cortex using sLASER at 3 T. A significant correlation between pain ratings and the anterior cingulate cortex is seen. As MRS moves towards becoming a standardized clinical technique, understanding the spatial distributions and variability will provide an important basis for the understanding of the healthy human brain’s biochemical environment.
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