Abstract #2022
T1 Weighted Postmortem MR Imaging of the Cerebellum at 3T: Preliminary Results between Feasibility and Desire
Matthias Weigel1,2,3, Riccardo Galbusera1,2, Peter Dechent4, Erik Bahn5, Govind Nair6, Ludwig Kappos1,2, Wolfgang Brück5, Christine Stadelmann5, and Cristina Granziera1,2
1Translational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel, Basel, Switzerland, 2Neurological Clinic and Policlinic, MS Center and Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel and University of Basel, Basel, Switzerland, 3Dept. of Radiology, Division of Radiological Physics, University Hospital Basel, Basel, Switzerland, 4Department of Cognitive Neurology, MR-Research in Neurology and Psychiatry, University Medical Center Göttingen, Göttingen, Germany, 5Institute of Neuropathology, University Medical Center Göttingen, Göttingen, Germany, 6Translational Neuroradiology Section, Division of Neuroimmunology and Neurovirology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States
Synopsis
MRI of the fixed human brain is highly interesting, since it basically allows very long scan times for unprecedented MRI resolutions on clinical scanners. Recent work utilized T2* weighted RF spoiled gradient echo sequences to achieve isotropic resolutions up to 160-microns at 3T. This work establishes a T1 weighted MR imaging protocol based on RF spoiled gradient echo sequences that currently enables isotropic resolutions of 240-microns at 3T and depicts the complex fine structure of the fixed cerebellum very well.
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