Microcephaly and intellectual disability is associated with mutation of the TRAPPC9 gene. A knockout mouse model of TRAPPC9-associated intellectual disability and microcephaly was characterised using high resolution T1 and T2 weighted Magnetic Resonance Imaging (MRI) and Diffusion Tensor Imaging (DTI) alongside behavioural assays. Behavioural differences suggested learning impairment in the model, MRI elucidated the developmental timeline of the disorder and highlighted several brain regions with reduced volume. DTI revealed reduced structural integrity in the corpus callosum.
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