Abstract #2024

Structural abnormalities in patients with early psychosis: a MP2RAGE-based morphometric study at 7T

Zirun Wang¹, Martine Cleusix², Raoul Jenni², Philippe Conus³, Kim Q. Do², and Lijing Xin¹

¹Animal imaging and technology core (AIT), Center for Biomedical Imaging (CIBM), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ²Center for Psychiatric Neuroscience, Department of Psychiatry, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, ³Service of General Psychiatry, Department of Psychiatry, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland

Synopsis

This study aims to investigate grey matter alterations in early psychosis patients (n = 44) compared to healthy control subjects (n=30). Morphometric analysis using MP2RAGE images at 7T. VBM did not reveal significant cluster after FWE (Family-Wise Error) corrections, but suggested grey matter reduction (uncorrected p<0.005) in the globus pallidus, right thalamus, left inferior temporal gyrus, left superior parietal, left paracentral lobule, left precuneus, right parietal lobe (postcentral gyrus) of patients compared to healthy subjects.

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