The detection of functional alterations in psychotic subjects has proven to be a demanding task. In this study we used ultrafast fMRI to investigate physiological brain pulsations driving blood and CSF convection in psychotic brain. We detected dichotomized changes in opposing brain region pulsations between the upper frontal and lower posterior parts of the brain in all three major brain pulsations. The altered brain pulsations in psychotic brains may be connected to abnormal convection of metabolites via CSF and blood providing an physiological basis for the altered reality experiences in psychosis.
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