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Abstract #2035

Pancreatic iron is a marker of cardiovascular complications in sickle cell disease

Antonella Meloni1, Laura Pistoia1, Massimiliano Missere2, Riccardo Righi3, Antonino Vallone4, Ada Riva5, Vincenzo Positano1, Luciana Rigoli6, Francesco Massei7, Valentina Carrai8, Gianna Alberini1, Filippo Cademartiri1, and Alessia Pepe1
1Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy, 2Gemelli Molise SpA, Fondazione di Ricerca e Cura "Giovanni Paolo II", Campobasso, Italy, 3Ospedale del Delta, Lagosanto (FE), Italy, 4Azienda Ospedaliera "Garibaldi" Presidio Ospedaliero Nesima, Catania, Italy, 5Ospedale “SS. Annunziata” ASL Taranto, Taranto, Italy, 6Policlinico "G. Martino", Messina, Italy, 7Azienda Ospedaliero Universitaria Pisana, Pisa, Italy, 8Azienda Ospedaliero - Universitaria Careggi, Firenze, Italy


We systematically explored the link between pancreatic iron detected by the T2* Magnetic Resonance Imaging technique and cardiovascular complications in a cohort of 63 patients with sickle cell disease (SCD). Patients with cardiovascular complications (supraventricular arrhythmias, heart failure, pulmonary hypertension, myocardial infarction, deep vein thrombosis, leg ulcers) showed significantly lower global pancreas T2* values than patients free of cardiovascular complications but comparable global heart T2* values. Pancreatic iron overload (T2*<26 ms) was associated with 7.5 times higher odds of cardiovascular complications.

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