Abstract #2035

Pancreatic iron is a marker of cardiovascular complications in sickle cell disease

Antonella Meloni¹, Laura Pistoia¹, Massimiliano Missere², Riccardo Righi³, Antonino Vallone⁴, Ada Riva⁵, Vincenzo Positano¹, Luciana Rigoli⁶, Francesco Massei⁷, Valentina Carrai⁸, Gianna Alberini¹, Filippo Cademartiri¹, and Alessia Pepe¹

¹Fondazione G. Monasterio CNR-Regione Toscana, Pisa, Italy, ²Gemelli Molise SpA, Fondazione di Ricerca e Cura "Giovanni Paolo II", Campobasso, Italy, ³Ospedale del Delta, Lagosanto (FE), Italy, ⁴Azienda Ospedaliera "Garibaldi" Presidio Ospedaliero Nesima, Catania, Italy, ⁵Ospedale “SS. Annunziata” ASL Taranto, Taranto, Italy, ⁶Policlinico "G. Martino", Messina, Italy, ⁷Azienda Ospedaliero Universitaria Pisana, Pisa, Italy, ⁸Azienda Ospedaliero - Universitaria Careggi, Firenze, Italy

Synopsis

We systematically explored the link between pancreatic iron detected by the T2* Magnetic Resonance Imaging technique and cardiovascular complications in a cohort of 63 patients with sickle cell disease (SCD). Patients with cardiovascular complications (supraventricular arrhythmias, heart failure, pulmonary hypertension, myocardial infarction, deep vein thrombosis, leg ulcers) showed significantly lower global pancreas T2* values than patients free of cardiovascular complications but comparable global heart T2* values. Pancreatic iron overload (T2*<26 ms) was associated with 7.5 times higher odds of cardiovascular complications.

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