1H-MRS of bile was performed in 54 healthy subjects at increased risk for metabolic diseases. Additionally, intrahepatic lipids (IHL) were quantified. Concentration of main peaks of bile was calculated in relation to non-suppressed water signal. Large interindividual differences in concentration of the bile-peaks with significantly lower concentrations in subjects with increased IHL were detected. Males show a tendency towards higher concentrations in all bile-peaks as well as in IHL (n.s.). It remains speculative, whether or not these MRS-derived results might play a role in the pathogenesis of insulin resistance – further analyses with assignable metabolic and laboratory data are recommended.
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