1H-MRS of bile in the gallbladder in subjects without and with hepatic steatosis
Jürgen Machann1,2,3, Norbert Stefan2,3,4, Andreas L Birkenfeld2,3,4, and Fritz Schick1
1Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany, 22. Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University of Tübingen, University of Tübingen, Tübingen, Germany, 33. German Center for Diabetes Research (DZD), Tübingen, Germany, 44. Department of Internal Medicine, Division of Endocrinology, Diabetology and Nephrology, University Hospital Tübingen, Tübingen, Germany
1H-MRS of bile was performed in 54 healthy subjects at increased risk for metabolic diseases. Additionally, intrahepatic lipids (IHL) were quantified. Concentration of main peaks of bile was calculated in relation to non-suppressed water signal. Large interindividual differences in concentration of the bile-peaks with significantly lower concentrations in subjects with increased IHL were detected. Males show a tendency towards higher concentrations in all bile-peaks as well as in IHL (n.s.). It remains speculative, whether or not these MRS-derived results might play a role in the pathogenesis of insulin resistance – further analyses with assignable metabolic and laboratory data are recommended.
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