MRI Tagging of Colonic Contents in Healthy Subjects: Reliability of the Measurement with Time
Meshari T Alshammari1,2, Luca Marciani1, Gordon W. Moran1, and Caroline L. Hoad3,4
1Translational Medical Sciences and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, United Kingdom, 2Department of Diagnostic Radiology, College of Applied Medical Sciences, University of Hail, Hail, Saudi Arabia, 3NIHR Nottingham Biomedical Research Centre (BRC), Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, United Kingdom, 4Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom
We aimed to investigate the temporal variation of the MR colonic tagging technique to measure mixing of colonic contents following a water based laxative drink by acquiring multiple scans on healthy participants. The study results indicate that time did not influence the measurement of colonic content mixing, however the scans were variable over the 10 minute acquisition window which suggests multiple scans are needed to accurately assess this parameter. Multiple measurements of this non-invasive technique can be used in future studies that aim to look at bowel motility and treatment response of IBD patients, using the same water-based laxative.
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