Analysis of organ metabolism with cancer growth can unravel systemic changes that occur with cancer and with cancer-induced cachexia. Cancer-induced cachexia, commonly observed with pancreatic cancer, causes tissue wasting, intolerance to chemotherapy, and poor quality of life. Here, we identified alterations of metabolic pathways in the spleen, liver, pancreas, lung, heart, brain and kidney following growth of cachexia-inducing and non-cachexia inducing pancreatic cancer xenografts. These results highlight the systemic metabolic changes that occur with cancer and with cancer induced cachexia that may lead to the development of organ-based early biomarkers as well to organ-based metabolic treatment strategies.
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