Abstract #2043

Assessment of microstructural changes associated with dyskinesia in hemiparkinsonian rodents

Maurizio Bergamino¹, Alberto Fuentes ¹, David J Marmion², Ivette M Sandoval², Christopher Bishop³, Fredric P Manfredsson², and Ashley M Stokes¹

¹Neuroimaging Division, Barrow Neurological Institute, Phoenix, AZ, United States, ²Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ, United States, ³Department of Psychology, Binghamton University, Binghamton, NY, United States

Synopsis

The objective of this pilot study was to assess white matter (WM) microstructural integrity in pre-clinical models of Parkinson’s disease using fractional anisotropy (FA) from diffusion tensor imaging (DTI). We assessed changes in FA in parkinsonian rats with levodopa-induced dyskinesia both over time and compared with control (sham) rats.

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