Assessment of microstructural changes associated with dyskinesia in hemiparkinsonian rodents
Maurizio Bergamino1, Alberto Fuentes 1, David J Marmion2, Ivette M Sandoval2, Christopher Bishop3, Fredric P Manfredsson2, and Ashley M Stokes1
1Neuroimaging Division, Barrow Neurological Institute, Phoenix, AZ, United States, 2Translational Neuroscience, Barrow Neurological Institute, Phoenix, AZ, United States, 3Department of Psychology, Binghamton University, Binghamton, NY, United States
The objective of this pilot study was to assess white matter (WM) microstructural integrity in pre-clinical models of Parkinson’s disease using fractional anisotropy (FA) from diffusion tensor imaging (DTI). We assessed changes in FA in parkinsonian rats with levodopa-induced dyskinesia both over time and compared with control (sham) rats.
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