Increased liver stiffness and shortened T2* relaxation time in people with type 2 diabetes
Yuliya Kupriyanova1,2, Pavel Bobrov2,3, Volker Burkart1,2, Vera Schrauwen-Hinderling1,2,4, and Michael Roden1,2,5
1Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany, 2German Center for Diabetes Research (DZD e.V.), München-Neuherberg, Germany, 3Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany, 4Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands, 5Department of Endocrinology and Diabetology, Medical Faculty and University Hospital, Heinrich Heine University, Düsseldorf, Germany
This study shows the value of multiparametric magnetic resonance measurements for detecting the changes in liver tissue due to diabetes mellitus. Liver fat content (determined by mDixon MRI and 1H-MR spectroscopy), T2* relaxation time and liver stiffness were compared in humans with type 1 (T1DM), type 2 diabetes mellitus (T2DM) or normal glucose tolerance (control, CON).
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