Association between neurofilament (NF-L) levels and amyotrophic lateral sclerosis (ALS) neurodegeneration patterns in the precentral cortex
Penelope Tilsley1,2, Antoine Moutiez3, Alexandre Brodovitch4, Mohamed Mounir El Mendili1,2, Wafaa Zaaraoui1,2, Annie Verschueren1,5, Shahram Attarian5, Maxime Guye1,2, José Boucraut4,6, Aude-Marie Grapperon1,5, and Jan-Patrick Stellmann1,2,3
1Aix Marseille Univ, CNRS, CRMBM, Marseille, France, 2APHM, Hôpital de la Timone, CEMEREM, Marseille, France, 3APHM, Hôpital de la Timone, Department of Neuroradiologie, Marseille, France, 4Immunology Laboratory, Conception Hospital, AP-HM, Marseille, France, 5APHM, Hôpital de la Timone, Referral Centre for Neuromuscular Diseases and ALS, Marseille, France, 6INS, INSERM, UMR 1106, Marseille, France
Neurofilament light-chain (NF-L) levels in serum and cerebrospinal fluid (CSF) have recently been demonstrated as robust clinical biomarkers in amyotrophic lateral sclerosis (ALS). Nonetheless, the association between NF-L levels and ALS specific neurodegeneration patterns in the precentral cortex, a primarily affected area, has not been fully divulged. Combining 3T and 7T anatomical imaging with NF-L measures, clinical and electrophysiological data, we demonstrated regional-specific degradation within the precentral cortex according to affected limb areas. Further, NF-L levels negatively correlated with cortical thickness within the premotor cortex, suggesting the premotor cortex may be an important contributor to augmented NF-L levels in ALS.
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