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Abstract #2049

Combined microstuctural and sodium homeostasis alterations in ALS are widespread in fast progressors: a brain DTI and sodium MRI study

Mohamed Mounir El Mendili1,2, Aude-Marie GRAPPERON2,3, Rémi DINTRICH 1,2,3, Jan patrick STELLMANN1,2, Lauriane PINI1,2, Claire COSTES1,2, Jean-Philippe RANJEVA1,2, Maxime GUYE 1,2, Annie VERSCHUEREN 3, Shahram ATTARIAN 3, and Wafaa ZAARAOUI 1,2
1Aix Marseille Univ, CNRS, CRMBM, Marseille, France, 2APHM, Hopital de la Timone, CEMEREM, Marseille, France, 3APHM, Hò‚pital de la Timone, Referral Centre for Neuromuscular Diseases and ALS, Marseille, France


Amyotrophic lateral sclerosis (ALS) is a heterogeneous condition showing variable progression rates. Conventional MRI lacks sensitivity and specificity to detect abnormalities in ALS and is mainly used to exclude ALS-mimics. Non-conventional MRI has gradually characterized specific neurodegeneration features in ALS.The present brain DTI and sodium MRI study evidenced combined microstructural and sodium homeostasis alterations in ALS and widespread damage in fast progressors. Our results confirm previous reports showing that non-conventional MRI technics might contribute to the diagnostic work-up of patients with different clinical profiles, especially when combined with mathematical modeling enabling predicting disease progression trajectory of a single patient.

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