Our investigations identified the precuneus as the brain region showing a major involvement in connectivity decline in patients with heart failure. Subsequent seed-based correlation analysis showed decreased putamen connectivity related to decline in cognitive performance. In line with these findings and with current Alzheimer’s Disease models showing precuneus connectivity decline as a key feature of brain degeneration, there might be common underlying mechanisms leading to brain connectivity decrease in heart failure and dementia. This hypothesis would be also supported by specific network centrality alterations between precuneus and widely distributed cortical regions particularly in patients showing reduced cognitive performance.
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