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Abstract #2050

Precuneus dysconnectivity with heart failure

Karsten Mueller1, Harald E Möller1, Birol Taskin1, Friederike Thiel1,2,3, Frank Beutner3,4, Andrej Teren3,4, Arno Arno Villringer1,2,3, and Matthias L Schroeter1,2,3
1Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2Clinic for Cognitive Neurology, University Hospital Leipzig, Leipzig, Germany, 3Leipzig Research Center for Civilization Diseases, Leipzig, Germany, 4Leipzig Heart Center, Leipzig, Germany


Our investigations identified the precuneus as the brain region showing a major involvement in connectivity decline in patients with heart failure. Subsequent seed-based correlation analysis showed decreased putamen connectivity related to decline in cognitive performance. In line with these findings and with current Alzheimer’s Disease models showing precuneus connectivity decline as a key feature of brain degeneration, there might be common underlying mechanisms leading to brain connectivity decrease in heart failure and dementia. This hypothesis would be also supported by specific network centrality alterations between precuneus and widely distributed cortical regions particularly in patients showing reduced cognitive performance.

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