3D MR spirometry sensitivity to gravity lung dependence in healthy volunteers
Nathalie Barrau1, Claire Pellot Barakat1, Zhongzheng He1, Tolga Emre1, Angéline Nemeth1, Anass Afkir1, Wenpei Cai1, Vincent Brulon1, Tanguy Boucneau2, Brice Fernandez2, Florent Besson1, Vincent Lebon1, and Xavier Maître1
1Université Paris-Saclay, CEA, CNRS, Inserm, BioMaps, Orsay, France, 2General Electric Healthcare, Buc, France
Spirometry is a standard exam in pulmonary function testing for assessing the efficiency of global ventilation from flow-volume loops measured at the mouth during forced respiratory cycles. A newly developed technique, 3D MR spirometry, makes use of dynamic magnetic resonance imaging during spontaneous breathing to produce regional characterization of the lung function. The sensitivity of the technique was challenged with respect to gravity by extracting the associated ventilation gradients in prone and supine healthy volunteers.
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