3D super-resolution MR elastography of the brain
Simone Hufnagel1, Matthias Anders2, Christoph Stefan Aigner1, Helge Herthum2, Heiko Tzschaetzsch2, Tobias Schaeffter1,3,4, Ingolf Sack2, and Christoph Kolbitsch1
1Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany, 2Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 3School of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom, 4Department of Biomedical Engineering, Technical University of Berlin, Berlin, Germany
MR elastography (MRE) provides valuable quantitative information about the mechanical properties of brain tissues. However, due to SNR limitations, often only low through-plane resolution is possible. We present super-resolution MRE based on multiple stacks of complex 3D wavefields of the brain resulting in elastograms with isotropic (1×1×1) mm3 resolution. The approach was evaluated for the in-vivo brain and showed improved visibility of fine structures while presenting consistent shear wave speed values.
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