Several proton magnetic resonance spectroscopy (1H-MRS) based studies have reported regional alterations of glutamate metabolism in both acute and chronic multiple sclerosis (MS) pathologies, including in normal appearing white matter and mixed tissues. Despite its well-established capability for detecting altered glutamate metabolism, 1H-MRS is hampered by the low spatial resolution that precludes the measurements from small MS lesions. We demonstrate the feasibility of performing glutamate weighted imaging using chemical exchange saturation transfer with B0- and B1- corrections in pediatric-onset MS subjects. The proposed model for B1-calibration is a major improvement over the phenomenological method previously proposed by our group.
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