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Abstract #2067

GluCEST in Deep Gray Matter and Adjoining White Matter of pediatric-onset Multiple Sclerosis Brains using a Robust B1-calibration Approach

Dushyant Kumar1, Ritobrato Datta2, Micky K Bacchus2, Narayan Datt Soni1, Ravi Prakash Reddy Nanga1, Brenda Banwell 2, and Ravinder Reddy1
1Radiology, Center for Advanced Metabolic Imaging in Precision Medicine (CAMIPM), University of Pennsylvania, Philadelphia, PA, United States, 2Neurology, Children's Hospital of Philadelphia, Philadelphia, PA, United States


Several proton magnetic resonance spectroscopy (1H-MRS) based studies have reported regional alterations of glutamate metabolism in both acute and chronic multiple sclerosis (MS) pathologies, including in normal appearing white matter and mixed tissues. Despite its well-established capability for detecting altered glutamate metabolism, 1H-MRS is hampered by the low spatial resolution that precludes the measurements from small MS lesions. We demonstrate the feasibility of performing glutamate weighted imaging using chemical exchange saturation transfer with B0- and B1- corrections in pediatric-onset MS subjects. The proposed model for B1-calibration is a major improvement over the phenomenological method previously proposed by our group.

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