Mapping myelin water exchange rates could potentially be useful in helping us understand and characterize different diseases in the brain. It is a challenging quantitative parameter mapping problem to estimate multi-compartment exchange. This work focuses on scan design, with an aim of estimating exchange maps with good precision. In particular, a set of balanced steady-state free precession (bSSFP) sequences are optimized to estimate exchange rates in white matter (WM), for a two-pool model. Quantitative exchange maps are shown for a simulated phantom, using this optimized scan design.
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