Abstract #2070

Using MRI-based fat fraction histograms in dystrophic muscle to assess individual patient disease evolution

Harmen Reyngoudt^1,2, Pierre-Yves Baudin^1,2, Ericky Caldas de Almeida Araujo^1,2, Brenda L Wong^3,4, Pierre G Carlier⁵, and Benjamin Marty^1,2

¹NMR Laboratory, Neuromuscular Investigation Center, Institute of Myology, Paris, France, ²NMR Laboratory, CEA/DRF/IBFJ/MIRCen, Paris, France, ³Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States, ⁴UMass Memorial Medical Center, Worcester, MA, United States, ⁵University Paris-Saclay, CEA, EA, DRF, Service Hospitalier Frédéric Joliot, Orsay, France

Synopsis

In most clinical quantitative MRI studies, using fat-water imaging, a mean fat fraction value per region of interest is generally used. The aim of this study was to look into the longitudinal changes in FF distribution on an individual patient basis, in dystrophic muscle, and at the same time, investigate whether differences were observed between treated and non-treated patients. As shown here, even if the mean fat fraction is the same between two patients or across time, there might be significant differences in the respective FF distributions, and might reveal, in retrospect, differential clinical or functional changes.

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