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Abstract #2071

Data-driven B1 non-uniformity correction in ultra-high-field small-animal macromolecular proton fraction and R1 mapping

Vasily L. Yarnykh1, Alena A. Kisel1, Andrey E. Akulov2, and Alexander Drobyshevsky3
1Radiology, University of Washington, Seattle, WA, United States, 2Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation, 3NorthShore University HealthSystem, Evanston, IL, United States


The data-driven surrogate B1 field correction algorithm was recently developed to eliminate B1-related spatial errors in the macromolecular proton fraction (MPF) and R1 maps obtained using the fast single-point method. The algorithm obviates the need for acquisition of actual B1 field maps, thus extending the routine use of fast MPF mapping. Initially, the surrogate B1 correction was applied to the human brain imaging at 3T. In this study, the method has been adopted and validated for small-animal imaging utilizing dedicated ultra-high-field MRI scanners. Particularly, we report guidelines on using surrogate B1 field correction in 9.4T and 11.7T magnetic fields.

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