Abstract #2072
Towards validation of in vivo U-fibre mapping using post-mortem DWI tractography of V1-V2 connections
Fakhereh Movahedian Attar1, Evgeniya Kirilina 1,2, Christian Schneider1,3, Daniel Haenelt1, Luke J. Edwards1, Kerrin J. Pine1, Carsten Jäger1,4, Katja Reimann1, Andreas Pohlmann5, Joao Periquito5,6, Tobias Streubel7, Siawoosh Mohammadi1,7, Thoralf Niendorf5,8, Markus Morawski4, and Nikolaus Weiskopf1,9
1Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2Department of Education and Psychology, Center for Cognitive Neuroscience Berlin, Free University Berlin, Berlin, Germany, 3Faculty of Physics and Earth Sciences, Leipzig University, Leipzig, Germany, 4Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany, 5Berlin Ultrahigh Field Facility, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, 6Institute of Physiology, Charité- Universitätsmedizin Berlin, Berlin, Germany, 7Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 8Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, 9Felix Bloch Institute for Solid State Physics, Faculty of Physics and Earth Sciences, Leipzig University, Leipzig, Germany
Synopsis
U-fibres are the most abundant white matter fibres and yet are highly underrepresented in the MRI-derived human brain connectome. Development of validated in vivo pipelines for comprehensive mapping of these short association fibres is therefore essential. Here, we show the correspondence of the geometries of U-fibres connecting early visual cortices mapped in vivo using sub-millimetre resolution diffusion weighted imaging (DWI) tractography to those obtained in a post-mortem brain tissue sample using ultra-high resolution DWI tractography.
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