Abstract #2073

Steady-state CEST-MRI using a reduced saturation period: Application to volumetric APT and rNOE brain imaging at 3T

Johannes Breitling¹, Andreas Korzowski¹, Mark E. Ladd^1,2,3, Peter Bachert^1,2, and Steffen Goerke¹

¹Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Faculty of Physics and Astronomy, University of Heidelberg, Heidelberg, Germany, ³Faculty of Medicine, University of Heidelberg, Heidelberg, Germany

Synopsis

In this study, we demonstrate the feasibility of obtaining steady-state 3D CEST contrasts of the human brain at 3T using a reduced saturation period. To this end, we applied our previous approach, which utilizes the analytical equation of the CEST signal, to an optimized clinical protocol using a fast volumetric snapshot-CEST acquisition. Measurements on model solutions and a volunteer demonstrated the feasibility with almost identical APT and rNOE contrasts for saturation durations as short as 1 second. Consequently, this facilitates quantitative CEST-MRI in humans within a reasonable and clinically relevant time frame.

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