Abstract #2074

Modelling inhomogeneous magnetization transfer in myelin and intra-/extra-cellular water in normal and injured rat spinal cords

Michelle H Lam^1,2, Andrew Yung², Jie Liu³, Wolfram Tetzlaff³, and Piotr Kozlowski^1,2,3,4

¹Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, ²UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, ³International Collaboration on Repair Discoveries, Vancouver, BC, Canada, ⁴Radiology, University of British Columbia, Vancouver, BC, Canada

Synopsis

An MR imaging technique called inhomogeneous magnetization transfer (ihMT) could potentially be used for quantitative myelin imaging by using T_1D filtering to filter out the short dipolar relaxation time (T_1D) components. However, to show that ihMT with T_1D filtering is myelin-specific, we need to confirm that myelin has the longest T_1D in nerve tissue. Here, we combined ihMT and myelin water imaging (MWI) to separate the ihMT signal in myelin water from intra-/extra-cellular water, which we fitted using a four-pool model with dipolar order reservoirs. Our model allowed us to connect myelin with myelin water and measure myelin’s T_1D.

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