Modelling inhomogeneous magnetization transfer in myelin and intra-/extra-cellular water in normal and injured rat spinal cords
Michelle H Lam1,2, Andrew Yung2, Jie Liu3, Wolfram Tetzlaff3, and Piotr Kozlowski1,2,3,4
1Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, 2UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, 3International Collaboration on Repair Discoveries, Vancouver, BC, Canada, 4Radiology, University of British Columbia, Vancouver, BC, Canada
An MR imaging technique called inhomogeneous magnetization transfer (ihMT) could potentially be used for quantitative myelin imaging by using T1D filtering to filter out the short dipolar relaxation time (T1D) components. However, to show that ihMT with T1D filtering is myelin-specific, we need to confirm that myelin has the longest T1D in nerve tissue. Here, we combined ihMT and myelin water imaging (MWI) to separate the ihMT signal in myelin water from intra-/extra-cellular water, which we fitted using a four-pool model with dipolar order reservoirs. Our model allowed us to connect myelin with myelin water and measure myelin’s T1D.
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