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Abstract #2075

comprehenCEST: a clinically feasible CEST protocol to cover all existing CEST preparations

Lukas Kamm1, Kai Herz2, Maria Sedykh1, Moritz Fabian1, and Moritz Zaiss1,2
1Neuroradiology, Friedrich-Alexander-University Erlangen-Nürnberg, University Hospital, Erlangen, Germany, 2Magnetic Resonance Center, Max-Planck-Institute for Biological Cybernetics, Tübingen, Germany


In a clinical setting, it often has to be decided, which CEST sequences to pick of a collection, due to measurement time limitations. Therefore, eventually not all of the desired contrasts can be measured. In this work, we comprehensively combine seven CEST protocols in a single measurement, use a fast single-shot 3D gradient echo readout and remove redundant regions of the experimental parameter space. Hereby, we can half the total measurement time from 35 to 17 minutes. With further parameter reduction, a total measurement time of 10 minutes is conceivable. This allows to design powerful hypothesis generating clinical pilot studies.

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