Abstract #2076

Repeatability of APTw imaging at 7T

Iris Obdeijn^1,2, Lejla Alic², Maarten Lequin^1,3, Sabine Plasschaert³, Wybe van der Kemp¹, Hans Hoogduin¹, Dennis Klomp¹, Jannie Wijnen¹, and Evita Wiegers¹

¹Department of Radiology, University of Medical Centre Utrecht, Utrecht, Netherlands, ²Magnetic Detection and Imaging Group, Technical Medical Centre, University of Twente, Enschede, Netherlands, ³Department of paediatric neuro-oncology, Princess Maxima Centre, Utrecht, Netherlands

Synopsis

APTw imaging is a potential imaging biomarker to assess treatment effects in brain tumours, especially at high field MRI (7T) due to improved signal-to-noise-ratio enabling the assessment of APTw values in heterogenous tumours. Embedding of APTw imaging in clinical decision making requires insight in the repeatability of APTw imaging. Therefore, we evaluated the repeatability of APTw imaging at 7T by using a phantom and in vivo in the human brain subjects. Repeatable and specific APTw maps were obtained at 7T, which facilitate the potential of detecting metabolic changes in brain tumours due to treatment.

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