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Abstract #2076

Repeatability of APTw imaging at 7T

Iris Obdeijn1,2, Lejla Alic2, Maarten Lequin1,3, Sabine Plasschaert3, Wybe van der Kemp1, Hans Hoogduin1, Dennis Klomp1, Jannie Wijnen1, and Evita Wiegers1
1Department of Radiology, University of Medical Centre Utrecht, Utrecht, Netherlands, 2Magnetic Detection and Imaging Group, Technical Medical Centre, University of Twente, Enschede, Netherlands, 3Department of paediatric neuro-oncology, Princess Maxima Centre, Utrecht, Netherlands


APTw imaging is a potential imaging biomarker to assess treatment effects in brain tumours, especially at high field MRI (7T) due to improved signal-to-noise-ratio enabling the assessment of APTw values in heterogenous tumours. Embedding of APTw imaging in clinical decision making requires insight in the repeatability of APTw imaging. Therefore, we evaluated the repeatability of APTw imaging at 7T by using a phantom and in vivo in the human brain subjects. Repeatable and specific APTw maps were obtained at 7T, which facilitate the potential of detecting metabolic changes in brain tumours due to treatment.

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