Optimization of Pulsed Chemical Exchange Saturation Transfer MRI by Optimal Control
Clemens Stilianu1, Christina Graf1, Clemens Diwoky2, Martin Soellradl1, Armin Rund3, Moritz Zaiss4, and Rudolf Stollberger1
1Medical Engineering, TU Graz, Graz, Austria, 2647 Institut für Molekulare Biowissenschaften, University of Graz, Graz, Austria, 3Institute for Mathematics and Scientific Computing, University of Graz, Graz, Austria, 4Department High-field Magnetic Resonance, Max Planck Institute Tübingen, Tübingen, Germany
We optimized CEST saturation pulse train using an optimal control framework and validated the simulation results on a preclinical scanner that allowed also Gold Standard continuous wave saturation. The optimized pulses almost reached the same saturation as the continuous wave pulse while addressing the allowed duty cycle and SAR limitations of clinical scanners. In measurements, the optimized pulses outperform state-of-the-art Gaussian pulses by over $$$47\%$$$.
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