Abstract #2083

CEST effects change with age

Angelika Barbara Mennecke¹, Katrin Khakzar¹, Alexander German¹, Kai Herz², Moritz Fabian¹, Andrzej Liebert³, Armin M. Nagel³, Frederik B. Laun³, Manuel Schmidt¹, Jürgen Winkler⁴, Arnd Dörfler¹, and Moritz Zaiss¹

¹Neuroradiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, ²Max Planck Institute for Biological Cybernetics, Tübingen, Germany, ³Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany, ⁴Neurology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany

Synopsis

The amide and rNOE CEST amplitudes are negatively correlated with age. Most prominently, the mean gray matter amide CEST amplitude decreases on average by 0.22 % per year of age in the cohort of our study.

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