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Abstract #2082

Optimization of pH-Weighted Contrasts in the Spinal Cord using Chemical Exchange Saturation Transfer (CEST) MRI

Alicia Cronin1,2, Patrick Liebig3, Sarah Detombe4, Neil Duggal1,4, and Robert Bartha1,2
1Medical Biophysics, Western University, London, ON, Canada, 2Centre for Functional and Metabolic Mapping, Robarts Research Institute, London, ON, Canada, 3Siemens Healthcare GmbH, Erlangen, Germany, 4Clinical Neurological Sciences, University Hospital, London Health Sciences Centre, London, ON, Canada


Degenerative cervical myelopathy (DCM) is a degenerative disease of the spine that leads to compression and neurological dysfunction. Recovery after surgery can be impacted by hypoxia in the cord, however the magnitude of this effect is currently unknown. Chemical Exchange Saturation Transfer (CEST) can produce contrast related to tissue pH, an indicator of hypoxia, but the method works best at ultra-high fields. Performing CEST in the spinal cord is also complicated by respiratory and cardiac motion and cerebrospinal fluid flow. The purpose of this work was to optimize pH-weighted CEST imaging in the human spinal cord at 3 Tesla.

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