Abstract #2085

Quantitative 3D Mapping of Cr and PCr Concentrations at 3T using Snapshot AREX CEST MRI

Or Perlman¹, Jaume Coll-Font^1,2, Kai Herz^3,4, Moritz Zaiss^3,5, Christopher Nguyen^1,2,6, and Christian T. Farrar¹

¹Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, ²Cardiovascular Research Center, Cardiology Division, Massachusetts General Hospital, Charlestown, MA, United States, ³Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, ⁴Department of Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany, ⁵Department of Neuroradiology, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), University Hospital Erlangen, Erlangen, Germany, ⁶Health Science Technology, Harvard-MIT, Cambridge, MA, United States

Synopsis

The dynamics of creatine and phosphocreatine distributions provide an important means for assessing metabolic function. While CEST-weighted MRI allows for the imaging of metabolite alterations, it is affected by semisolid-MT, spillover, and T₁ contributions, and is typically analyzed on a two-dimensional image, given the inherently long acquisition times. Here, we performed 3D quantitative mapping of Cr and PCr concentrations in the human calf muscle at 3T, using a rapid snapshot-CEST protocol followed by apparent exchange-dependent relaxation (AREX) analysis. Significant (p<0.001) changes in the concentrations of both creatine and phosphocreatine were measured during exercise, in agreement with the literature.

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