Quantitative 3D Mapping of Cr and PCr Concentrations at 3T using Snapshot AREX CEST MRI
Or Perlman1, Jaume Coll-Font1,2, Kai Herz3,4, Moritz Zaiss3,5, Christopher Nguyen1,2,6, and Christian T. Farrar1
1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, 2Cardiovascular Research Center, Cardiology Division, Massachusetts General Hospital, Charlestown, MA, United States, 3Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 4Department of Biomedical Magnetic Resonance, University of Tübingen, Tübingen, Germany, 5Department of Neuroradiology, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), University Hospital Erlangen, Erlangen, Germany, 6Health Science Technology, Harvard-MIT, Cambridge, MA, United States
The dynamics of creatine and phosphocreatine distributions provide an important means for assessing metabolic function. While CEST-weighted MRI allows for the imaging of metabolite alterations, it is affected by semisolid-MT, spillover, and T1 contributions, and is typically analyzed on a two-dimensional image, given the inherently long acquisition times. Here, we performed 3D quantitative mapping of Cr and PCr concentrations in the human calf muscle at 3T, using a rapid snapshot-CEST protocol followed by apparent exchange-dependent relaxation (AREX) analysis. Significant (p<0.001) changes in the concentrations of both creatine and phosphocreatine were measured during exercise, in agreement with the literature.
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