Chronic anemia is commonly observed in patients with hemoglobinopathies, mainly represented by disorders in hemoglobin structure (e.g., sickle cell anemia, SCA) and hemoglobin synthesis (e.g., thalassemia syndrome). These hemoglobin disorders have been associated with white matter alterations. In this study, changes in white matter connectivity on chronic anemic patients were characterized by quantifying the volumetric mean of fractional anisotropy along the pathway of tracks connecting two ROIs (defined by BrainSuite’s BCI-DNI atlas) and comparing it with healthy individuals. SCA patients showed interhemispheric FA derangements but not to the same extent as changes observed in the watershed areas of non-SCA patients.
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