Neuroimaging studies have shown that juvenile myoclonic epilepsy (JME) is characterized by impaired brain networks. However, few studies have investigated the potential disruptions in the rich club organization. Our study described the alterations of anatomical rich club organization and abnormalities of dynamic SC-FC coupling in treatment-naïve newly diagnosed JME. The results showed that the anatomical rich club organization was disrupted in the patient group, along with decreased connectivity strength among rich club hub nodes. The aberrant dynamic SC-FC coupling of rich club organization suggests a selective influence of interconnected network core in JME at the early phase of the disease.
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