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Abstract #2110

Cerebellum structural and functional connectivity alteration in relation to freezing of gait in Multiple system atrophy

Huaguang Yang1, Weiyin Vivian Liu2, Liang Li1, Zhi Wen1, and Yunfei Zha1
1Renmin Hospital of Wuhan University, Wuhan, China, 2GE Healthcare, Beijing, China


Cerebellum is responsible for posture and gait control. 67% of patients with multiple system atrophy experienced FOG. Patients with the damaged cerebellar locomotor region had gait-freezing-like symptoms, suggesting that the cerebellum may be involved in the occurrence and development of FOG symptoms. This study suggested that the cerebellum volume atrophy may be involved in FOG development in MSA patients and subsequently induce functional abnormality in the cerebellum-cerebral circuit. This study provided neuroimaging evidence for clinical understanding of cerebellum role in MSA patients with FOG injury.

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