Effect of a lifestyle intervention with plant-based diet on liver and muscle lipids in metabolic syndrome-associated osteoarthritis patients
C.S. de Jonge1, C.A. Wagenaar2,3, W. Walrabenstein2,3, M.A. Troelstra1, A.J. Nederveen1, and D. van Schaardenburg2,3
1Amsterdam UMC, University of Amsterdam, Department of Radiology and Nuclear Medicine, Amsterdam Gastroenterology Endocrinology Metabolism, Meibergdreef 9, Amsterdam, Netherlands, 2Amsterdam Rheumatology and Immunology Center, Reade, 1056 AB, Amsterdam, Netherlands, 3Amsterdam UMC, Amsterdam Medical Center, 1105 AZ, Amsterdam, Netherlands
The aim of this study was to evaluate the effect of a 16-week multidisciplinary lifestyle intervention with a plant-based diet on hepatocellular, intra- and extramyocellular lipid levels in patients with metabolic syndrome-associated osteoarthritis as measured by proton MR spectroscopy. The intervention group (n=17) was compared with the control group receiving usual care (n=15). At the end of the intervention the intervention group showed reduced hepatocellular lipid levels and total body fat mass and improved metabolic and inflammatory markers compared to the control group. There was no observable change of intra- and extramyocellular lipid levels.
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