The aim of this study was to evaluate the effect of a 16-week multidisciplinary lifestyle intervention with a plant-based diet on hepatocellular, intra- and extramyocellular lipid levels in patients with metabolic syndrome-associated osteoarthritis as measured by proton MR spectroscopy. The intervention group (n=17) was compared with the control group receiving usual care (n=15). At the end of the intervention the intervention group showed reduced hepatocellular lipid levels and total body fat mass and improved metabolic and inflammatory markers compared to the control group. There was no observable change of intra- and extramyocellular lipid levels.
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