Shutter Speed Model based Quantitative DCE-MRI for Therapeutic Response Assessment of Pancreatic Ductal Adenocarcinoma: A Pilot Study
Martin Dawson Holland1, David A Hormuth2, Xiaoyu Jiang3, Chase D Christenson4, Desiree E Morgan5, Yufeng Li5, Junzhong Xu3, Thomas E Yankeelov4, and Harrison Kim5
1Medicine, University of Alabama at Birmingham, Birmingham, AL, United States, 2The University of Texas at Austin, Austin, TX, United States, 3Vanderbilt University, Nashville, TN, United States, 4University of Texas at Austin, Austin, TX, United States, 5University of Alabama at Birmingham, Birmingham, AL, United States
Shutter Speed Model (SSM) based Ktrans, ve, kep, and τi in the pancreatic tumors before initiating chemotherapyt were 0.081±0.036 mm-1, 0.258±0.070, 0.320±0.152 mm-1, and 0.247±0.197 μs, respectively, without statistical difference between the responding and non-responding groups. The Ktrans in the tumors favorably responding to chemotherapy increased 72±14%, significantly larger than in the non-responding tumors (2±9%, p=0.0001). The ve in the responding tumors also significantly increased compared to the non-responding group (64±25% vs 3±9%, p=0.0036). However, no statistical difference was found between the responding and non-responding groups in either kep (6±11% vs 11±16%, p=0.6204) or τi (3±47% vs 147±280%, p=0.3408).
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