Development of an Efficient MRE/MRI Protocol for Multiparametric Assessment of Liver, Spleen, and Kidneys to Diagnose Hepatorenal Syndrome
Nana Owusu1, Zheng Zhu1, Jiahui Li1, Kevin Glaser1, Yi Sui1, Douglas Simonetto2, Patrick Kamath2, Vijay Shah2, Sudhakar Venkatesh3, Richard Ehman1, and Meng Yin1
1Radiology, Mayo Clinic, Rochester, MN, United States, 2Gastroenterology, Mayo Clinic, Rochester, MN, United States, 3Mayo Clinic, Rochester, MN, United States
An efficient imaging protocol was developed to facilitate diagnosis of hepatorenal syndrome in patients with decompensated cirrhosis. Multiparametric MRI for quantifying perfusion, diffusion, and blood oxygenation, as well as multiparametric MRE for quantifying viscoelasticity and tissue pressure were optimized in preparation for the pilot study predicting hepatorenal syndrome. Results demonstrate the feasibility of the multiparametric protocol and provide motivation for commencing clinical testing.
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