Abstract #2137

Initial Observations on the Association of Peri-prostatic Vascular Asymmetry and Extra-prostatic Extension of Prostatic Tumors

Paul E Summers¹, Alessia Minchillo², Sarah Alessi¹, Giuseppe Renne³, Ottavio De Cobelli^4,5, Gennaro Musi^4,5, Giulia Marvaso^4,6, Barbara Alicja Jereczek-Fossa^4,6, and Giuseppe Petralia^4,7

¹Division of Radiology, IEO, European Institute of Oncology IRCCS, Milano, Italy, ²University of Milan, Milano, Italy, ³Uropathology and Intraoperative Diagnostics, IEO, European Institute of Oncology IRCCS, Milano, Italy, ⁴Department of Oncology and Hemato-oncology, University of Milan, Milano, Italy, ⁵Division of Urology, IEO, European Institute of Oncology IRCCS, Milano, Italy, ⁶Division of Radiation Oncology, IEO, European Institute of Oncology IRCCS, Milano, Italy, ⁷Precision Imaging and Research Unit, IEO, European Institute of Oncology IRCCS, Milano, Italy

Synopsis

We hypothesized that the presence of asymmetry in the arterial supply of the prostate may provide a correlate of extra-prostatic tumor extension in patients with prostate cancer. In this preliminary study of 40 patients (20 with and 20 without extra-prostatic disease), a radiologist blind to the status of the patients, made a binary choice as to the presence or absence of peri-prostatic vascular asymmetry. Taking the pathological grading as the reference standard, the sensitivity, specificity, positive and negative predictive values were all 0.9. The negative likelihood ratio (LR-) was 0.11, and the positive likelihood ratio (LR+) was 9.0.

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