Fat fraction (FF) mapping using whole-body MRI is clinically valuable for the assessment of treatment response in diseases such as multiple myeloma. MRI FF maps can be accurately measured using multi-point acquisitions such as mDixon-Quant, however, they are not feasible for whole-body acquisitions. We have previously developed a “dark-fat” masking algorithm that can account for residual fat signal in water-only images from 2-point Dixon fat/water separation, that are readily feasible with whole-body MRI. In this study, we demonstrate the utility of this algorithm across a range of proton-density FF using a multi-compartment commercial FF phantom.
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