Magnetic resonance (MR) chemical shift thermometry (CST) is the only method that can approximate absolute rather than relative temperature. Our goal was to evaluate repeated body and brain MR CST measurements and the brain-body temperature gradient in healthy human volunteers over a short time period. While brain, body, or the difference between brain and body temperatures were not significantly different, variations in brain temperature between measurements were observed suggesting fluctuations over short time periods. Further investigation into the time scale of brain temperature fluctuations, particularly under controlled conditions to account for physiological changes and neural activity, are warranted.
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