Evaluation of Repeated MR Chemical Shift Brain Thermometry in Healthy Humans
Kelly J. Wang1,2, Dongsuk Sung2,3, Benjamin B. Risk4, Jason W. Allen2,3, and Candace C. Fleischer2,3
1Department of Neuroscience, Georgia Institute of Technology, Atlanta, GA, United States, 2Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States, 3Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, GA, United States, 4Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, United States
Magnetic resonance (MR) chemical shift thermometry (CST) is the only method that can approximate absolute rather than relative temperature. Our goal was to evaluate repeated body and brain MR CST measurements and the brain-body temperature gradient in healthy human volunteers over a short time period. While brain, body, or the difference between brain and body temperatures were not significantly different, variations in brain temperature between measurements were observed suggesting fluctuations over short time periods. Further investigation into the time scale of brain temperature fluctuations, particularly under controlled conditions to account for physiological changes and neural activity, are warranted.
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