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Abstract #2175

Fluorinated Tm3+-complexes as molecular temperature sensors

Felix Mysegaes1,2, Pauline Voigt1, Isabell Prediger2, Johannes Bernarding2, and Markus Plaumann2
1Institut für Organische und Analytische Chemie, University of Bremen, Bremen, Germany, 2Institute of Biometry and Medical Informatics, Otto-von-Guericke University Magdeburg, Medical Faculty, Magdeburg, Germany


Temperature is an important factor for various physiological phenomena. Hyperthermia and hypothermia are only two examples in clinical application. As the resolution of MR data increases, so does interest in the exact determination of the temperature. Molecular sensors offer the opportunity to determine temperature in living organisms. Based on the preliminary investigations of our working group using Ce3+ complexes, the more detailed characterization of Tm3+ complexes was carried out with regard to the temperature sensitivity of the 19F MR signals and, for the first time, also to the toxicity using the example of fibroblasts.

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