Temperature is an important factor for various physiological phenomena. Hyperthermia and hypothermia are only two examples in clinical application. As the resolution of MR data increases, so does interest in the exact determination of the temperature. Molecular sensors offer the opportunity to determine temperature in living organisms. Based on the preliminary investigations of our working group using Ce3+ complexes, the more detailed characterization of Tm3+ complexes was carried out with regard to the temperature sensitivity of the 19F MR signals and, for the first time, also to the toxicity using the example of fibroblasts.
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