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Abstract #2188

Ultra-high resolution human functional imaging using 10.5 Tesla

Luca Vizioli1,2, Steen Moeller1, Andrea Grant1, Nader Tavaf1, Alireza Sadeghi-Tarakameh1, Yigitcan Eryaman1, Jerahmie Radder1, Russell Lagore1, Pierre-François Van de Moortele1, Edward Auerbach1, Gregor Adriany1, Essa Yacoub1, and Kamil Ugurbil1
1CMRR, University of Minnesota, Minneapolis, MN, United States, 2Department of Neurosurgery, University of Minnesota, Minneapolis, MN, United States


With the development of accelerated acquisition protocols, it is possible to achieve functional brain mapping with submillimeter resolution. This permits studying the human brain at the mesoscopic scale. Typical submillimeter images measure 0.8 mm. isotropic voxels, barely enough to study human functional mesoscopic responses. Here we acquire functional images at 10.5 T with the unprecedented spatial resolution of 0.4 mm. isotropic voxels. Using NORDIC to suppress thermal noise, we demonstrate the feasibility of achieving meaningful brain mapping at these ultra-high resolutions, where single voxels contains but a few thousand cells, further bridging the gap between fMRI and optical imaging

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