Combining Arterial Blood Contrast with BOLD improves fMRI laminar specificity.
Nikos Priovoulos1, Icaro Agenor Ferreira de Oliveira1, Benedikt A Poser2, David Norris3, and Wietske van der Zwaag1
1Spinoza Center for Neuroimaging, Amsterdam, Netherlands, 2MR-Methods group, MBIC, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands, 3Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, Netherlands
BOLD fMRI is widely applied in human neuroscience, but is limited in its spatial specificity compared to cerebral blood volume approaches due to its venous bias. Here we added cerebral blood-volume weighting based on magnetization transfer (Arterial Blood Contrast) to a BOLD submillimeter acquisition at 7T. Adding Arterial Blood Contrast helped differentiate the deep and superficial cortical responses in the human primary motor cortex. The results suggest that combining Arterial Blood Contrast with BOLD can improve the fMRI spatial specificity while retaining high sensitivity.
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