Abstract #2202

Global network disruption in focal to bilateral tonic-clonic seizures.

Christina Maher^1,2, Arkiev D'Souza¹, Michael Barnett^1,3,4, Omid Kavehei^2,5, Armin Nikpour⁴, and Chenyu Wang^1,3

¹Brain and Mind Centre, The University of Sydney, Sydney, Australia, ²School of Biomedical Engineering, Faculty of Engineering, University of Sydney, Sydney, Australia, ³Sydney Neuroimaging and Analysis Centre, Sydney, Australia, ⁴Department of Neurology, Royal Prince Alfred Hospital, Sydney, Australia, ⁵ARC Centre for Innovative Bioengineering, The University of Sydney, Sydney, Australia

Synopsis

Focal to bilateral tonic-clonic seizures (FBTCS) are a feature of focal epilepsy, characterised by seizures that spread contralaterally to the origin of ictal discharge. Widespread global network disruption has been shown in patients with FBTCS compared to those with focal epilepsy. A structure-function relationship has been proposed, suggesting the role of the underlying subcortical structures in network alterations. Disease duration has been associated with whole-brain network disruption. Global network disruption may be a subtle marker in differentiating the likelihood of developing FBTCS, allowing treatment to be tailored.

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