Global network disruption in focal to bilateral tonic-clonic seizures.
Christina Maher1,2, Arkiev D'Souza1, Michael Barnett1,3,4, Omid Kavehei2,5, Armin Nikpour4, and Chenyu Wang1,3
1Brain and Mind Centre, The University of Sydney, Sydney, Australia, 2School of Biomedical Engineering, Faculty of Engineering, University of Sydney, Sydney, Australia, 3Sydney Neuroimaging and Analysis Centre, Sydney, Australia, 4Department of Neurology, Royal Prince Alfred Hospital, Sydney, Australia, 5ARC Centre for Innovative Bioengineering, The University of Sydney, Sydney, Australia
Focal to bilateral tonic-clonic seizures (FBTCS) are a feature of focal epilepsy, characterised by seizures that spread contralaterally to the origin of ictal discharge. Widespread global network disruption has been shown in patients with FBTCS compared to those with focal epilepsy. A structure-function relationship has been proposed, suggesting the role of the underlying subcortical structures in network alterations. Disease duration has been associated with whole-brain network disruption. Global network disruption may be a subtle marker in differentiating the likelihood of developing FBTCS, allowing treatment to be tailored.
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