Abstract #2201
Brain GABA and glutathione measurements in convalescent COVID-19 subjects
Muhammad G. Saleh1, Linda Chang1,2,3, Huajun Liang1, Meghann C Ryan1, Eric Cunningham1, Eleanor Wilson4, Andrea R Levine5, Shyamasundaran Kottilil5, and Thomas Ernst1
1Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, 2Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, United States, 3Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 4Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, United States, 5Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, United States
Synopsis
COVID-19 infection was associated with lower plasma levels of glutathione (GSH), provoking oxidative stress; however, whether GSH levels are also lower in the brain is unknown. COVID-19 survivors (COVID+) also have higher prevalence of psychiatric disorders, possibly due to altered brain GABA. However, brain GABA and GSH levels have not been assessed in convalescent COVID-19 (COVID+) individuals. Using edited MRS, frontal grey matter (FGM) GSH were lower in male COVID+, and COVID+ individuals had greater age-related decline in FGM GSH, compared to uninfected controls. These findings suggest that male COVID+ individuals, especially the older subjects, are susceptible to oxidative stress.
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