Abstract #2205

Inflammation and reduced cortical perfusion assessed by renal MRI during acute kidney injury in critically ill COVID-19 patients

Eleanor F Cox¹, Tomas Luther², Per Eckerbom³, Jan Weis⁴, Fredrik Palm⁵, Robert Frithiof², Per Liss³, and Susan T Francis¹

¹Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ²Section of Anesthesiology, Dept of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden, ³Section of Radiology, Dept of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden, ⁴Department of Medical Physics, Uppsala University Hospital, Uppsala, Sweden, ⁵Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden

Synopsis

Acute kidney injury (AKI) is associated with increased mortality in COVID-19 patients. Multiparametric MRI was performed to study renal perfusion, oxygenation and tissue structure in nineteen COVID-19 intensive care patients. Results are compared between patients with and without COVID-19 associated AKI, and with healthy volunteers (HV). Cortical perfusion was lower in COVID-19 compared to HVs (P=0.0002) with cortex and medullary perfusion lower in AKI compared to non-AKI (P<0.03). Correlations between cortex measures in COVID-19 showed T₁ was positively correlated with T₂ and ADC, and T₂ was positively correlated with ADC and T₂* suggesting interstitial oedema resulting from inflammation.

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