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Abstract #2205

Inflammation and reduced cortical perfusion assessed by renal MRI during acute kidney injury in critically ill COVID-19 patients

Eleanor F Cox1, Tomas Luther2, Per Eckerbom3, Jan Weis4, Fredrik Palm5, Robert Frithiof2, Per Liss3, and Susan T Francis1
1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2Section of Anesthesiology, Dept of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden, 3Section of Radiology, Dept of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden, 4Department of Medical Physics, Uppsala University Hospital, Uppsala, Sweden, 5Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden


Acute kidney injury (AKI) is associated with increased mortality in COVID-19 patients. Multiparametric MRI was performed to study renal perfusion, oxygenation and tissue structure in nineteen COVID-19 intensive care patients. Results are compared between patients with and without COVID-19 associated AKI, and with healthy volunteers (HV). Cortical perfusion was lower in COVID-19 compared to HVs (P=0.0002) with cortex and medullary perfusion lower in AKI compared to non-AKI (P<0.03). Correlations between cortex measures in COVID-19 showed T1 was positively correlated with T2 and ADC, and T2 was positively correlated with ADC and T2* suggesting interstitial oedema resulting from inflammation.

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