Lower Cerebral Venous Oxygenation in Post-acute Sequelae of COVID-19
Peiying Liu1, Thomas Ernst1, Huajun Liang1, Dengrong Jiang2, Eric Cunningham1, Zixuan Lin2, Meghann C. Ryan1,3, Hanzhang Lu2, Eleanor Wilson4, Andrea Levine4, and Linda Chang1
1Department of Diagnostic Radiology & Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, 2Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD, United States, 4Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, United States
Post-COVID Syndrome (PCS) is highly prevalent amongst COVID-19 survivors. Neuropsychiatric symptoms are often reported in patients with PCS, suggesting brain involvement in the early stages of COVID-19. One potential etiology is the cerebral microcirculation dysfunction due to SARS-CoV-2 infection, which may affect oxygen delivery and consumption in the brain. In the present study, we investigated the changes in cerebral venous oxygenation, which reflects the balance between oxygen supply and consumption, in convalescent COVID-19 participants with PCS. Our results showed that participants with PCS had altered venous oxygenation in their brain, which was also associated with slower locomotion.
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