Abstract #2207

Lower Cerebral Venous Oxygenation in Post-acute Sequelae of COVID-19

Peiying Liu¹, Thomas Ernst¹, Huajun Liang¹, Dengrong Jiang², Eric Cunningham¹, Zixuan Lin², Meghann C. Ryan^1,3, Hanzhang Lu², Eleanor Wilson⁴, Andrea Levine⁴, and Linda Chang¹

¹Department of Diagnostic Radiology & Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, ²Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD, United States, ⁴Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, United States

Synopsis

Post-COVID Syndrome (PCS) is highly prevalent amongst COVID-19 survivors. Neuropsychiatric symptoms are often reported in patients with PCS, suggesting brain involvement in the early stages of COVID-19. One potential etiology is the cerebral microcirculation dysfunction due to SARS-CoV-2 infection, which may affect oxygen delivery and consumption in the brain. In the present study, we investigated the changes in cerebral venous oxygenation, which reflects the balance between oxygen supply and consumption, in convalescent COVID-19 participants with PCS. Our results showed that participants with PCS had altered venous oxygenation in their brain, which was also associated with slower locomotion.

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