Post-acute COVID-19 syndrome (PACS) is an umbrella term for the long-term symptoms and poor quality-of-life that follow acute SARS-CoV-2 viral-infection in up to 7/10 COVID-19 survivors. The mechanistic understanding of PACS remains poorly understood, which stymies treatment decision-making. In a PACS pilot study, we evaluated hyperpolarized 129Xe MRI ventilation defect percent and texture features to measure potential longitudinal changes. There were no significant differences in 129Xe MRI ventilation texture measurements six-months and 12-months after a baseline visit (12 weeks post-infection). PACS participants exhibited abnormal second-order 129Xe MRI ventilation textures and patchy ventilation, relative to healthy controls, 6-12 months post-infection.
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