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Abstract #2208

Post-Acute COVID-19 Syndrome: Longitudinal 129Xe MRI Ventilation Heterogeneity Measurements

Harkiran K Kooner1,2, Marrissa J McIntosh1,2, Maksym Sharma1,2, Gaurav V Singh3, Neha Nasir3, Emily Blake3, Inderdeep Dhaliwal4, Michael Nicholson4, Miranda Kirby3, and Grace Parraga1,2,4
1Robarts Research Institute, London, ON, Canada, 2Department of Medical Biophysics, Western University, London, ON, Canada, 3Department of Physics, Ryerson University, Toronto, ON, Canada, 4Division of Respirology, Department of Medicine, Western University, London, ON, Canada


Post-acute COVID-19 syndrome (PACS) is an umbrella term for the long-term symptoms and poor quality-of-life that follow acute SARS-CoV-2 viral-infection in up to 7/10 COVID-19 survivors. The mechanistic understanding of PACS remains poorly understood, which stymies treatment decision-making. In a PACS pilot study, we evaluated hyperpolarized 129Xe MRI ventilation defect percent and texture features to measure potential longitudinal changes. There were no significant differences in 129Xe MRI ventilation texture measurements six-months and 12-months after a baseline visit (12 weeks post-infection). PACS participants exhibited abnormal second-order 129Xe MRI ventilation textures and patchy ventilation, relative to healthy controls, 6-12 months post-infection.

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