Many patients who recover from COVID-19 have symptoms that persist long after the acute phase of the disease has subsided, including fatigue and dyspnea on exertion. There is an unmet need for understanding the diverse cardiac and pulmonary causes of these symptoms and to monitor patients longitudinally. We imaged N=6 subjects with long-haul COVID using both cardiac MRI and hyperpolarized 129Xe MRI and spectroscopy. While cardiac imaging did not reveal structural or functional abnormalities, we observed a wide variety of findings on 129Xe MRI, with subjects who had been hospitalized exhibiting the most pronounced gas exchange impairment.
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