Hyperpolarized 129Xe MRI is sensitive to variations in gas exchange impairment in patients with long haul COVID-19
David Mummy1, Elianna Bier2, Junlan Lu3, Suphachart Leewiwatwong2, Aryil Bechtel4, Isabelle Dummer5, Sakib Kabir1, Jennifer Korzekwinski1, Katherine Williford 6, Shelby Martindale6, Coral Giovacchini6, David Shaz6, Joseph Mammarappallil1, Fawaz Alenezi6, Raymond Kim6, Bastiaan Driehuys1, and Loretta Que6
1Radiology, Duke University, Durham, NC, United States, 2Biomedical Engineering, Duke University, Durham, NC, United States, 3Medical Physics, Duke University, Durham, NC, United States, 4Physics, Duke University, Durham, NC, United States, 5Bioengineering, McGill University, Montreal, QC, Canada, 6Medicine, Duke University, Durham, NC, United States
Many patients who recover from COVID-19 have symptoms that persist long after the acute phase of the disease has subsided, including fatigue and dyspnea on exertion. There is an unmet need for understanding the diverse cardiac and pulmonary causes of these symptoms and to monitor patients longitudinally. We imaged N=6 subjects with long-haul COVID using both cardiac MRI and hyperpolarized 129Xe MRI and spectroscopy. While cardiac imaging did not reveal structural or functional abnormalities, we observed a wide variety of findings on 129Xe MRI, with subjects who had been hospitalized exhibiting the most pronounced gas exchange impairment.
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