Brain stiffness correlates with hematocrit
Jakob Seja1, Bernhard Kreft2, Helge Herthum2, Mehrgan Shahryari3, Jürgen Braun2, Ingolf Sack3, and Stefan Hetzer1
1Berlin Center for Advanced Neuroimaging, Charité - Universitätsmedizin Berlin, Berlin, Germany, 2Institute of Medical Informatics, Charité - Universitätsmedizin Berlin, Berlin, Germany, 3Radiology department, Charité - Universitätsmedizin Berlin, Berlin, Germany
The viscosity of blood scales with the concentration of red blood cells (hematocrit) and potentially influences the viscoelasticity of the perfused tissue. In this study, cerebral MR elastography (MRE) was applied to a group of healthy subjects to analyze the interrelation between mechanical properties of brain tissue and the hematocrit. We found a highly significant positive correlation between in-vivo mechanical properties of cerebral tissue and hematocrit level (p<0.0001).
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