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Abstract #2265

Brain-wide olfactory aberrations in a Parkinson’s Disease mouse model revealed by functional MRI

Ruxanda Lungu1, Francisca F Fernandes1, Tiago Fleming Outeiro2, and Noam Shemesh1
1Shemesh Lab, Champalimaud Foundation, Lisbon, Portugal, 2Experimental Neurodegeneration, University of Goettingen, Goettingen, Germany


Parkinson's disease (PD) is associated with irreparable damage to dopaminergic neurons in brain areas involved in movement. Frequently, a very early symptom is an impaired sense of smell, but the associated brain-wide mechanisms remain unclear. Here, we report on aberrations in BOLD-fMRI responses along olfactory pathway in a PD mouse model. We find decreased activation, especially in the main olfactory bulb, olfactory tubercle and piriform cortex in PD mice when compared to healthy controls upon olfactory stimulation.

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